The action of strontium, a trace mineral, is closely related to that of calcium and the retention of strontium varies inversely with intake. It affects the osteoporetic process by inhibiting the activity of the 24, 25 hydroxy forms of vitamin D3 in animals. It has been shown that treating postmenopausal women with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures. Low levels have been found in patients with dental caries, decreased growth in animals, bone pain and osteoporosis. Toxic levels may cause dental caries, rickets, abdominal pain and diarrhea.
No RDA has been established for strontium. An estimated mean daily intake of strontium worldwide from food and water is 1.0 mg to 5.0 mg per day. A therapeutic range is said to be from 10 mg to 2000 mg. Sources of strontium are most plant foods, dairy products, brazil nuts, and seawater.
A 20-mL random or 24 hour urine specimen is required for this test.
REFERENCES:
- Meunier, P.J., Roux, C.R., et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350:2001-2003:459-468.
- Strewler, G.J. Osteoporsis Therapy at the 10-year mark. N Engl J Med 2004; 350: 1172-1174.
- CPT CODE:
- 82190
- COLLECTION CONTAINER:
- Clean container
- STATE & SHIPPING RESTRICTIONS:
- We cannot ship lab kits to NY, AK, HI, or international
- MINIMUM VOLUME:
- 10 mL
- NORMAL VALUES:
- Random 0.012 - 0.132 ug/mL / 24 Hour 39 - 166 ug/24 hrs
- PATIENT PREP:
- None
- PROCESS METHOD:
- The methodology is by ICP. Normal values established in our laboratory are:
- PROCESS TIME:
- 5 to 7 business days
- SPECIMEN VOLUME:
- 20 mL urine
- SYNONYMS:
- Urine Sr
- TRANSPORT CONTAINER:
- Plastic transport tube
- TRANSPORT INSTRUCTIONS:
- Refrigerate or freeze
