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Selenium, RBC

$105.00
SHIPPING RESTRICTIONS:
Please note that lab kits cannot be shipped to
New York, Alaska, Hawaii, or internationally.
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SKU:
LRbcSe
Selenium (Se) is a constituent of glutathione peroxidase, an antioxidant enzyme that breaks down hydrogen peroxide, phospholipid hydroperoxides and other free hydroperoxides. There are four selenium atoms in glutathione peroxidase. There are three types of iodothyronine deiodinase. It removes iodine from thyroid hormone molecules, activates T4 and inactivates T3. Type I in the cells of the liver, kidney and thyroid converts T3 from T4. Type II is found in the brain, brown fat, pituitary and converts T4 to T3 and regulates TSH secretion, Type III inactivates T3.
 
Se in food is related to the soil selenium. Keshan disease in China (a selenium deficiency resulting from low Se in the soil in Keshan, China) results in an enlarged heart and congestive heart failure. Kashin-Beck is an endemic osteoarthritis caused by selenium deficiency. Se deficiency in male and female rats has resulted in infertility. Chronic selenosis (selenium toxicity) results in loss of hair and nails, skin lesions, tooth decay & nervous system disorders. Acute Se poisoning results in nausea, vomiting, hair loss, nail changes, irritability, fatigue and neuropathy.
 
Good sources of Se are foods grown in Se rich soil, tuna, seafoods, meats and whole grains.
 
The RDA is 55 ug/day.
 
REFERENCES:
  • Tietz Textbook of Clinical Chemistry, 3rd Ed. 1999, W. B. Saunders and Company, Chapter 30.
  • Arnaud, J., et al.: Nutritional biological markers of deficiencies of zinc, copper, and selenium. Ann. Biol. Clin.,51:589-604, 1993.
  • Arthur, J.R., Beckett, G.J.: Roles of selenium in type I iodothyronine-5Æ-deiodinase and in thyroid hormone and iodine metabolism. In: R.F. Burk, Ed. Selenium in biology and human health. New York, Springer-Verlag, 1994, pp. 93-115.
CPT CODE:
84255
COLLECTION CONTAINER:
Heparin tube
STATE & SHIPPING RESTRICTIONS:
We cannot ship lab kits to NY, AK, HI, or international
MINIMUM VOLUME:
0.5 mL
NORMAL VALUES:
The expected values in our laboratory for Se are: RBC = 75 to 240 ug/L
PATIENT PREP:
None
PROCESS METHOD:
The methodology is by atomic absorption/ICP.
PROCESS TIME:
5 to 7 business days
REJECTION CAUSES:
Specimen clotted.
SPECIAL INSTRUCTIONS:
None
SPECIMEN VOLUME:
1.5 mL Heparin RBC, washed 1x
SYNONYMS:
RBC Se
TRANSPORT CONTAINER:
Metal-free plastic transport tube
TRANSPORT INSTRUCTIONS:
Refrigerate or freeze