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Vitamin A, C, E, B12, Folate Profile
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    Vitamin A, C, E, B12, Folate Profile

    Product Code: LVAF

    Price: $284.00

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    Test Description

    Vitamin A, C, E, B12, Folate Profile

    Vitamin A

    Some of the functions of vitamin A are in the body's vision, mucous membranes, cell division, skin maintenance, sperm production, egg development, growth, bone development and cancer prevention. Symptoms indicate a deficiency of vitamin A in the body include poor vision, night blindness, "bumps" on skin, lower disease resistance, stunted growth, pregnancy problems, acne, and xerosis.

    Preformed vitamin A is found mainly in animal meats. Beta carotene is composed of two vitamin A molecules and is found in green or orange vegetables, and fruits. These include carrots, squash, spinach, apricots, etc. The RDA for vitamin A is 3000 I.U. per day. A supplemental dose could range from 5000 to 10,000 I.U. A toxic dose may occur at 25,000 to 50,000 I.U. The body will convert beta carotene to vitamin A if the thyroid is functioning properly and the patient does not have diabetes. These two conditions may lead to a high serum beta carotene and low serum vitamin A.

    Vitamin A is measured in serum which must be protected from light.

    Vitamin C - Plasma

    Vitamin C is also called ascorbic acid. There have been over 7000 articles written about vitamin C. It is a strong water-soluble antioxidant. Vitamin C stimulates the immune system in seven different ways and is important in collagen formation. It is important in the synthesis of connective tissue, and in wound healing. It helps regulate lipids in blood, iron absorption and is important in synthesis of hormones in stress situations. It helps regenerate vitamin E in the body. It is found in many fruits and vegetables such as sweet peppers, broccoli, cauliflower, lemons, strawberries, asparagus, spinach, oranges, cantaloupe, grapefruit and tomatoes.

    Deficiency of vitamin C results in the classical disease of scurvy. Other conditions are pain in joints, slow wound healing, lower disease resistance, easy bruising, bleeding gums, loose teeth, irritability, premature wrinkling and aging of skin. Like most other vitamins, humans cannot make vitamin C.

    The RDA for vitamin C is 75 mgs for females, 90 mgs for males. A suggested supplemental dose is 100 to 2000 mg.

    Specimen collection, preparation and transport is of vital importance for accurate results. Collect the specimen in a cold heparin or EDTA tube. Place tube in ice water and centrifuge immediately. Place 3.0 mL of plasma in 4.5 mL of cold 3% metaphosphoric acid (MPA, supplied with kit). Mix vigorously and freeze. Ship frozen in the MPA tube.

    Vitamin E

    Vitamin E is a fat-soluble vitamin. There are eight forms of vitamin E, however, the most biologically active form is d-alpha-tocopherol. The best defined role for vitamin E is an antioxidant for unsaturated fatty acids in cell membranes. It is also important in energy metabolism and synthesis of RNA, DNA, and red blood cells. It acts as an antioxidant in the lungs against smog. Vitamin E is absorbed in the presence of bile in the small intestine. Deficiency of vitamin E may result in hemolysis of RBCs, sterility, higher risk for heart disease and stroke.

    The RDA is 22 I.U. A suggested supplemental range is 100 to 1000 I.U. A toxic range has not been established, but 4000 I.U. and higher should be taken with caution.

    Specimen required is 0.5 mL of serum protected from light and shipped in an amber plastic tube.

    Vitamin B12

    B12 contains a mineral, cobalamin, and is sometimes referred to as cyancobalamin. The test is run on serum, usually in conjunction with folate (folic acid). B12 is a water-soluble vitamin. It is necessary for DNA and red blood cell synthesis, new cell growth, maintenance of nervous tissue and glucose metabolism. It is also one of the vitamins (along with B6 and folate) essential to convert homocysteine back to methionine. Decreased levels can cause anemia (pernicious anemia), fatigue, irritability, loss of appetite, labored breathing, constipation, heart palpitations, headache and "sore tongue." Some congenital defects have been linked to low B12 levels. It is found in liver, oysters, poultry, fish, clams, salmon and eggs. B12 tends to be low in vegans.

    The RDA is 2.4 micro grams. A supplemental level is 3 to 1000 micrograms. There is no toxic dose listed for B12.

    Specimen required is 1.0 mL of serum, protected from light.

    Folate (Folic Acid, Folacin)

    Folate is a member of the "B" vitamin family and is water-soluble. The test is usually run on serum in conjunction with B12. It is necessary for new cell growth, especially the lining of the G.I. tract, the surface of the tongue and in pregnancy. It helps mobilize fat from the liver, and is necessary for the synthesis of red and white blood cells. It serves as a precursor for nucleic acids and as a repair mechanism for DNA. It serves as a methyl donor and helps convert homocysteine back to methionine. Decreased levels can cause anemia (megaloblastic anemia), growth problems, birth defects (spinal bifida), fatigue, poor memory (Alzheimer's disease), sore tongue, digestive problems, toxemia of pregnancy, and an increased risk for strokes and heart attacks.

    Folate is found in liver, salmon, eggs, whole wheat, asparagus, and green leafy vegetables. It is added to all cereal grains.

    The RDA is 400 micrograms. A suggested supplemental level is 400 to 2000 micrograms. There is no toxic dose listed for folic acid.

    Doctors who wish to order kits, please call our lab directly to set up an account before ordering. 316-684-7784

    Test Details

    Process time: 5 to 7 business days

    Process method: The methodology is by HPLC for Vitamin A, Vitamin C Plasma, Vitamin E. For Vitamin B12 and Folate the methodology is an RIA method using a 57CO as a label and is performed on serum or plasma.

    CPT code: 84590; 82180; 84446; 82607; 82746

    Special instructions: See instructions for vitamins A, E, B12, Folate & Plasma C. Vitamins A & E may share the same specimen tube. Vitamin B12 & Folate may share the same specimen tube.

    Collection Instructions

    Patient prep: None

    Collection instructions: Click here for PDF


    Normal values:

    Vitamin A: 24 to 90 ╡g/dL.
    Vitamin C û Plasma: 0.6 to 2.0 mg/dL.
    Vitamin E: 0.6 to 2.7 mg/dL.
    Vitamin B12: 165 to 1100 pg/mL.
    Folate: Not Specified

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