Product Code: LRbcSe
Selenium (Se) is a constituent of glutathione peroxidase, an antioxidant enzyme that breaks down hydrogen peroxide, phospholipid hydroperoxides and other free hydroperoxides. There are four selenium atoms in glutathione peroxidase. There are three types of iodothyronine deiodinase. It removes iodine from thyroid hormone molecules, activates T4 and inactivates T3. Type I in the cells of the liver, kidney and thyroid converts T3 from T4. Type II is found in the brain, brown fat, pituitary and converts T4 to T3 and regulates TSH secretion, Type III inactivates T3.
Se in food is related to the soil selenium. Keshan disease in China (a selenium deficiency resulting from low Se in the soil in Keshan, China) results in an enlarged heart and congestive heart failure. Kashin-Beck is an endemic osteoarthritis caused by selenium deficiency. Se deficiency in male and female rats has resulted in infertility. Chronic selenosis (selenium toxicity) results in loss of hair and nails, skin lesions, tooth decay & nervous system disorders. Acute Se poisoning results in nausea, vomiting, hair loss, nail changes, irritability, fatigue and neuropathy.
Good sources of Se are foods grown in Se rich soil, tuna, seafoods, meats and whole grains.
The RDA is 55 ug/day.
Doctors who wish to order kits, please call our lab directly to set up an account before ordering. 316-684-7784
Process time: 5 to 7 business days
Process method: The methodology is by atomic absorption/ICP.
CPT code: 84255
Special instructions: None
Rejection causes: Specimen clotted.
Patient prep: None
Specimen volume: 1.5 mL Heparin RBC, washed 1x
Minimum volume: 0.5 mL
Collection container: Heparin tube
Transport container: Metal-free plastic transport tube
Transport instructions: Refrigerate or freeze
Collection instructions: Click here for PDF
Normal values: The expected values in our laboratory for Se are: RBC = 75 to 240 ug/L
Reference one: Tietz Textbook of Clinical Chemistry, 3rd Ed. 1999, W. B. Saunders and Company, Chapter 30.
Reference two: Arnaud, J., etal.: Nutritional biological markers of deficiencies of zinc, copper, and selenium. Ann. Biol. Clin.,51:589-604, 1993.
Reference three: Arthur, J.R., Beckett, G.J.: Roles of selenium in type I iodothyronine-5Æ-deiodinase and in thyroid hormone and iodine metabolism. In: R.F. Burk, Ed. Selenium in biology and human health. New York, Springer-Verlag, 1994, pp. 93-115.
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