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Selenium, RBC
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    Selenium, RBC

    Product Code: LRbcSe

    Price: $105.00

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    Test Description

    Selenium, RBC

    Selenium (Se) is a constituent of glutathione peroxidase, an antioxidant enzyme that breaks down hydrogen peroxide, phospholipid hydroperoxides and other free hydroperoxides. There are four selenium atoms in glutathione peroxidase. There are three types of iodothyronine deiodinase. It removes iodine from thyroid hormone molecules, activates T4 and inactivates T3. Type I in the cells of the liver, kidney and thyroid converts T3 from T4. Type II is found in the brain, brown fat, pituitary and converts T4 to T3 and regulates TSH secretion, Type III inactivates T3.

    Se in food is related to the soil selenium. Keshan disease in China (a selenium deficiency resulting from low Se in the soil in Keshan, China) results in an enlarged heart and congestive heart failure. Kashin-Beck is an endemic osteoarthritis caused by selenium deficiency. Se deficiency in male and female rats has resulted in infertility. Chronic selenosis (selenium toxicity) results in loss of hair and nails, skin lesions, tooth decay & nervous system disorders. Acute Se poisoning results in nausea, vomiting, hair loss, nail changes, irritability, fatigue and neuropathy.

    Good sources of Se are foods grown in Se rich soil, tuna, seafoods, meats and whole grains.

    The RDA is 55 ug/day.

    Test Details

    Process time: 5 to 7 business days

    Process method: The methodology is by atomic absorption/ICP.

    CPT code: 84255

    Special instructions: None

    Rejection causes: Specimen clotted.

    Collection Instructions

    Patient prep: None

    Specimen volume: 1.5 mL Heparin RBC, washed 1x

    Minimum volume: 0.5 mL

    Collection container: Heparin tube

    Transport container: Metal-free plastic transport tube

    Transport instructions: Refrigerate or freeze

    Collection instructions: Click here for PDF


    Normal values: The expected values in our laboratory for Se are: RBC = 75 to 240 ug/L


    Reference one: Tietz Textbook of Clinical Chemistry, 3rd Ed. 1999, W. B. Saunders and Company, Chapter 30.

    Reference two: Arnaud, J., etal.: Nutritional biological markers of deficiencies of zinc, copper, and selenium. Ann. Biol. Clin.,51:589-604, 1993.

    Reference three: Arthur, J.R., Beckett, G.J.: Roles of selenium in type I iodothyronine-5Æ-deiodinase and in thyroid hormone and iodine metabolism. In: R.F. Burk, Ed. Selenium in biology and human health. New York, Springer-Verlag, 1994, pp. 93-115.

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