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Lipid Profile
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    Lipid Profile

    Product Code: LLip

    Price: $119.00

     
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    Test Description

    Lipid Profile

    The lipid profile includes cholesterol, triglycerides, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and various risk classifications for coronary heart disease (CHD), cholesterol to HDL ratio, and LDL to HDL ratio.

    Profile Includes Cholesterol; triglycerides; high-density lipoprotein (HDL); very low-density lipoprotein (VLDL); low-density lipoprotein (LDL) & risk classification for coronary heart disease (CHD); cholesterol to HDL ratio & risk classification for CHD; LDL to HDL ratio & risk classification for CHD

    Cholesterol

    Total cholesterol is used to measure lipid status and metabolic disorders. Cholesterol is necessary for life, but is also associated with atherosclerosis. It is used to make hormones, vitamin D, and cell membranes. About two-thirds of the body's cholesterol is made by the liver and one-third obtained through the diet. Increased cholesterol is found in high fat diets, primary hypercholesterolemia, the nephritic syndrome, hypothyroidism, primary biliary cirrhosis and in some cases of diabetes. Low levels have been found in malnutrition, malabsorption, severe liver disease, polycythemia vera, etc.

    The method is by spectrophotometry

    Normal values are based on age. The "normal or reference ranges" has been lowered in recent years to combat the rapid increase in heart disease. In people under 19 years of age, the normal value is less than 170 mg/dL. In people over 19 years of age, the normal value is less than 200 mg/dL.

    Triglycerides

    Like cholesterol, triglycerides (TG) are used to measure lipid status and metabolic disorders. A patient must absolutely be fasting for an accurate measurement. Triglycerides are the major component of chylomicrons and VLDL, two types of lipoproteins. They may be elevated in hypothyroidism, diabetes, chronic liver and kidney diseases, pancreatitis, some genetic types of hyperlipidemia, alcohol abuse, estrogen (pregnancy or oral contraceptive pills), and certain medications (thiazide diuretics). The triglyceride level is used to calculate the LDL, however, to get a correct answer, the TG must be 400 mg/dL or less. A turbid serum specimen indicates a TG level of around 400 mg/dL.

    The method is by spectrophotometry.

    The ATP III guidelines recommends:

    Unit (mg/dL) 
    < 150 normal
    150 - 199 borderline-high
    200 - 499 high
    500 very high

    HDL (High-Density Lipoprotein)

    HDL is called the "good cholesterol". It tends to carry cholesterol away from tissues. All other risk factors considered, a high HDL is a good risk factor.

    The method is by spectrophotometry.

    The ATP III guideline recommends:

    Unit (mg/dL) 
    < 40 low
    > 60 high

    LDL (Low-Density Lipoprotein)-Calculated

    LDL cholesterol is called the "bad cholesterol". It is part of the lipid profile and is one of the more important risk factors for atherosclerotic (CHD) disease. LDL is the cholesterol component that binds to liver receptors and tends to control the formation of cholesterol.

    The method is by calculation using the Friedewald formula. The formula can only be used when the TG are less than 400 mg/dL. LDL core lipids contains about 10% TG and 45% cholesterol.

    The ATP III Guidelines recommend:

    Unit (mg/dL) 
    < 100 optimal
    100 - 129 near optimal
    130 - 159 borderline high
    160 - 189 high
    > 190 very high

    Very Low Density Lipoprotein (VLDL)

    VLDL is a type of lipoprotein and helps carry triglycerides to the liver and other parts of the body. Density refers to the amount of lipids per lipoprotein versus proteins. Core lipids in chylomicrons contain about 85% triglycerides and 5% cholesterol, VLDL contains about 60% TG and 15% cholesterol. Elevated VLDL levels are found in Type IV hyperlipidemias.

    Cholesterol to HDL Ratio

    The Cholesterol to HDL ratio is a calculation of your risk for heart disease. It is optimal to have a low ratio. A low ratio indicates that total cholesterol is comprised mostly of HDL particles. This ratio is considered the most important indicator for atherosclerosis.

    Risk Classification Male Female
    1/2 Average Risk < 3.4 < 3.3
    Average Risk 3.4 - 5.03.3 - 4.4
    2 Times Average Risk 5.1 - 9.6 4.5 - 7.1
    3 Times Average Risk 9.7 - 23.0 7.2 - 11.0

    LDL to HDL Ratio

    The LDL to HDL ratio is also a heart disease risk indicator. It is best to have a low ratio as this indicates there is sufficient HDL in relation to LDL to aid in prevention of atherosclerosis. Excessively high or low levels can indicate a problem. It is best to maintain these in proper balance to HDL.

    Risk Classification Male Female
    1/2 Average Risk < 1.0 < 1.5
    Average Risk 1.0 - 3.6 1.5 - 3.2
    2 Times Average Risk 3.7 - 6.3 3.3 - 5.0
    3 Times Average Risk6.4 - 8.0 5.1 - 6.1



    Doctors who wish to order kits, please call our lab directly to set up an account before ordering. 316-684-7784

    Test Details

    Process time: 5 to 7 business days

    Process method: The methodology is by spectrophotometry.

    CPT code: 80061

    Special instructions: None

    Rejection causes: Gross Hemolysis

    Collection Instructions

    Patient prep: Fasting

    Specimen volume: 4 mL serum

    Minimum volume: 1.5 mL

    Collection container: SST or red-stopper tube

    Transport container: Plastic transport tube

    Transport instructions: Refrigerate or freeze

    Collection instructions: Click here for PDF

    References

    Reference one: NIH Publication No. 01-3305, JAMA, 285:2486-97, May, 2001.

    Reference two: Report of the National Cholesterol Treatment Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Arch Intern Med,1988, 148:36-9.

    Reference three: Vance, D.E., Vance, J.E. Biochemistry of Lipids, Lipoproteins, and Membranes. New York, Elsevier Science, 1996.

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