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    Close Histamine


    Product Code: LHis

    Price: $184.00

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    Test Description


    Histamine is a reactive amine. Most histamine is found in platelets, tissue mast cells and basophils. Basophils are probably the source of most blood histamine. Histamine is a major neurotransmitter in the brain, especially in the hippocampus and throughout the autonomic nervous system. The measurement of blood histamine is important in studies of psychiatric, rheumatic, allergic and neurologic disorders. High blood histamine levels (histadelia) have been found in 20% of schizophrenics and other psychiatric disorders such as depression, "blank mind," obsessive-compulsive disorders and phobias. Low histamine levels (histapenia) is found in about 50% of schizophrenics and results in hyperactivity, mania, paranoia, hallucinations and abnormal ideas.

    Specimen is whole blood drawn in a plain tube. Draw last if other tubes are collected. Do not allow blood to clot. Mix well and add 2 mL of whole blood to 5.0 mL of 10% trichloroacetic acid. Mix well and freeze.

    Test Details

    Process time: 5 to 7 business days

    Process method: The methodology for histamine is a fluorescent method following an ion-exchange separation technique.

    CPT code: 83088

    Special instructions: None

    Rejection causes: Inadequate specimen added to TCA aliquot; specimen not frozen.

    Collection Instructions

    Patient prep: Discontinue antihistamines two days before collection of specimen

    Specimen volume: Draw until blood stops flowing into tube provided by Bio Center Lab. These tubes will draw blood to just below the black mark on the label. Immediately transfer unclotted blood into 5 mL 10% trichloroacetic acid (TCA). Mix specimen well by vigorously shaking TCA tube after adding blood. Stable one month if kept frozen. Note: Histamine, Spermidine & Spermine testing may all three be performed from a single specimen (i.e. separate aliquots are not required).

    Minimum volume: same

    Collection container: Non-additive tube; draw this tube last if other tubes are being collected from the patient; do not allow whole blood to clot

    Transport container: Plastic transport tube

    Transport instructions: Freeze

    Collection instructions: Click here for PDF


    Normal values: The reference value established in our laboratory for histamine is 33 to 65 ng/mL.


    Reference one: Jackson, J.A., Riordan, H.D., Neathery, S., Revard, C. Histamine levels in health and diseases. Jour OrthoMol Med. 1998. 13(4); pp236-240.

    Reference two: Pfeiffer, C.C., Smyrl, E.G., Iliev. Extreme basophil counts and blood histamine levels in schizophrenic patients as compared to normals. Res Commun Chem Pathol Pharmacol, 1972a; 4:51.

    Reference three: Schwartz, J.C. Histamine as a transmitter in brain. Life Sci, 1975; 17: 503-517.

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